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KMID : 0859320060240040237
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Journal of the Korean Society for Therapeutic Radiology and Oncology
2006 Volume.24 No. 4 p.237 ~ p.242
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Treatment Outcome of Locally Advanced Non-small Cell Lung Cancer
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Lee Heui Kwan
Kwon Hyoung-Cheol
Lee Sun-Young
Kim Jung-Soo
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Abstract
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Purpose: We evaluated retrospectively the outcome of locally advanced non-small cell lung cancer patients
treated with definitive radiotherapy to find out prognostic factros affecting survival.
Materials and Methods: 216 cases of stage IIIB non-small cell lung cancer were with treated radiotherapy at
our Hospital between 1991 to 2002 and reviewed retrospectively. Cases were classified by mode of treatment
and response to treatment. Patients showing complete response or partial response to treatment were included
in the “response group”, while those showing stable or progressive cancer were included in the “nonresponse
group”.
Results: 30 patients completed the planned radiotherapy treatments and 39 patients completed combined
treatments or chemoradiotherapy. Median survival was 4.6 months for patients treated with radiotherapy and 9.9
months for those undergoing combined radiotherapy and chemotherapy. Survival rates for the first year were
13.3% with radiotherapy and 35.9% with chemoradiotherapy. In the second year, 3.3% of the radiotherapy
patients survived and 20.5% of the patients receiving chemoradiotherapy survived. By the third year, 15.4% of
the patients receiving the combined treatments survived. None of the patients treated with radiotherapy alone
lived to the third year, however. Overall survival was significantly different between the radiotherapy patients and
the combined chemoradiotherapy patients (p＜0.001). In the response group, median survival was 7.2 months
with radiotherapy and 16.5 months with combined therapy. In the non-response group, median survival was 4.4
months with radiotherapy and 6.7 months with combined treatments. Severe acute complications (grade 3)
occurred in 2 cases using radiotherapy, and in 7 cases using combined therapy .
Conclusion: When the patients with stage IIIB non-small cell lung cancer received chemoradiotherapy,
treatment response rate and overall survival was greater than with radiation alone.
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KEYWORD
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Non-small cell lung carcinoma, Radiotherapy, Survival
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